Sökning: "biomarkör"

Visar resultat 11 - 15 av 36 avhandlingar innehållade ordet biomarkör.

  1. 11. Molecular basis for galectin-ligand interactions : Design, synthesis and analysis of ligands

    Författare :Kristoffer Peterson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galectin; Structure-based design; Thiodigalactoside; Huisgen 1; 3-dipolar cycloaddition; Protein-ligand binding interactions;

    Sammanfattning : Galectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. LÄS MER

  3. 12. Real-time breath gas analysis of carbon monoxide : laser-based detection and pulmonary gas exchange modeling

    Författare :Ramin Ghorbani; Florian M. Schmidt; Anders Blomberg; Christoffer Boman; Staffan Schedin; Jonathan Beauchamp; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbon monoxide CO ; pulmonary gas exchange; computational modeling; real-time breath gas analysis; single-exhalation profile; laser absorption spectroscopy; nonlinear least-squares fitting; breath sampling; baseline level; diurnal variation; healthy population; exposure study; fysik; Physics; Physiology; fysiologi;

    Sammanfattning : Breath gas analysis is a promising approach for non-invasive medical diagnostics and physiological monitoring. Real-time, breath-cycle resolved biomarker detection facilitates data interpretation and has the potential to improve the diagnostic value of breath tests as exhalation profiles carry spatiotemporal information about biomarker origin and gas exchange in the respiratory tract. LÄS MER

  4. 13. Testosterone Use and Abuse : Methodological Aspects in Forensic Toxicology and Clinical Diagnostics

    Författare :Yvonne Lood; Jeanette Wahlberg; Johan Ahlner; Bertil Ekman; Elisabeth Aardal; Martin Josefsson; Ingemar Thiblin; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Abuse of anabolic androgenic steroids (AAS) is widespread in society and is today a major public health problem, associated with mental and somatic adverse effects and risk behavior, such as use of other illicit drugs and criminality. Testosterone, the most important endogenous male androgen, is therapeutically used in replacement therapy but is also extensively used as a doping agent. LÄS MER

  5. 14. FROM SERUM TO TISSUE: GALECTIN-BINDING GLYCOFORMS OF SERUM GLYCOPROTEINS AS FUNCTIONAL BIOMARKERS

    Författare :Michael Carlsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Galectin; glycoproteins; intracellular sorting; biomarkers;

    Sammanfattning : Galectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now suggests important roles of galectins in both cancer and inflammation. LÄS MER

  7. 15. Gastrointestinal Permeability and Motility in Inflammatory Bowel Disease

    Författare :Anas Kh. Al-Saffar; Per Hellström; Dominic-Luc Webb; Åsa Keita; Uppsala universitet; []
    Nyckelord :Gastrointestinal motility; intestinal permeability; Mucosal; Ghrelin; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Synchronized motility, permeability and secretory (hormones and enzymes) events are integral to normal physiology. Smooth muscle syncytium operates with enteric nervous system (ENS) and endocrine signalling to accommodate, mix and control passage of ingested materials. LÄS MER