Sökning: "autoantigen"

Visar resultat 21 - 25 av 66 avhandlingar innehållade ordet autoantigen.

  1. 21. Ro52 antibodies and susceptibility genes in congenital heart block

    Författare :Linn S Strandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnancy, the autoantibodies cross the placenta and affect the fetus in which a potentially lethal atrioventricular (AV) block may develop. LÄS MER

  3. 22. Studies of immune mechanisms in myasthenia gravis

    Författare :Biying Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :myasthenia gravis; acetylcholine receptor; ß-adrenergic receptor; antibody; T cell receptor; antibody-dependent cell-mediated cytotoxicity; gene polymorphism;

    Sammanfattning : Myasthenia gravis (MG) has been considered the prototype of autoantibody-mediated autoimmune diseases. The pathogenic autoantibodies are directed against the acetylcholine receptor (AChR). Several mechanisms by which these antibodies (AChR Ab) disturb the function of the receptor have been elucidated. LÄS MER

  4. 23. Mechanisms and modulation of experimental allergic encephalomyelitis as basis for treatment of multiple sclerosis

    Författare :Ling-Yun Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Its etiology is unknown and there exists no cure. LÄS MER

  5. 24. Study of autoimmune reactions in rheumatoid arthritis

    Författare :Evan Reed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects approximately 1% of the population worldwide. Despite being rather common, the etiopathology of RA remains unclear. LÄS MER

  7. 25. Aspects of autoantibody epitopes in type 1 diabetes

    Författare :Hanna Skärstrand; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Minor autoantigens Neuropeptide Y.; Affinity; ZnT8 autoantibodies; Autoimmune type 1 diabetes;

    Sammanfattning : Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. LÄS MER