Sökning: "autoantigen"

Visar resultat 11 - 15 av 66 avhandlingar innehållade ordet autoantigen.

  1. 11. Pituitary autoantibodies in endocrine disorders

    Författare :Sophie Bensing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lymphocytic hypophysitis; hypopituitarism; empty sella syndrome; APS 1; autoantibodies; autoantigen; Secretogranin II; TDRD6.;

    Sammanfattning : Autoimmune endocrine disorders are characterised by the development of autoantibodies to specific autoantigens in the target organs. Lymphocytic hypophysitis (LyH) is a disease characterised by inflammation of the pituitary gland, often resulting in hypopituitarism. The aetiology of LyH is considered to be autoimmune. LÄS MER

  3. 12. The role of Ro52 autoantibodies in congenital heart block

    Författare :Stina Salomonsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Autoantibodies; Ro52; congenital heart block CHB ; Sjögren s syndrome SS ; autoimmunity; inflammation; autoantigen; germinal center GC ;

    Sammanfattning : The presence of B cells producing autoantibodies is a common feature of many autoimmune conditions. The pathogenic role of the autoantibodies is often unclear, but they often serve as diagnostic markers and may be used as prognostic tools in some diseases. LÄS MER

  4. 13. Identification of autoantigens in multiple sclerosis

    Författare :Mattias Bronge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system in which cells from primarily the adaptive immune system infiltrate the brain and spinal cord, leading to inflammation and demyelination. Debuting primarily between 20-40 years of age and with a prevalence in Sweden of ~0. LÄS MER

  5. 14. Studies on molecular regulation of inflammation in cutaneous lupus erythematosus

    Författare :Vilija Oke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lupus erythematosus (LE) is an autoimmune disease with a wide range of clinical manifestations. This spectrum spans from limited cutaneous disease to life-threatening rheumatic disorder involving vital organs. Sun exposure is an evident exogenous trigger of both cutaneous (CLE) and systemic LE (SLE). LÄS MER

  7. 15. Molecular Targets in Autoimmune Polyendocrine Syndrome Type1 and Their Clinical Implications

    Författare :Mohammad Alimohammadi; Olle Kämpe; Anna Lobell; Fredrik Rorsman; Tommy Olsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; autoantibodies; endocrinology; parathyroid; hypoparathyroidism; Addison s disease; pulmonary symptoms; NALP; NALP5; NLR; KCNRG; Molecular medicine; Molekylär medicin;

    Sammanfattning : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. LÄS MER