Sökning: "TCR activation"

Visar resultat 6 - 10 av 76 avhandlingar innehållade orden TCR activation.

  1. 6. Heavy Metal Superantigen : Genetic Regulation of Lymphocyte Activation by HgC12

    Författare :Yun Jiang; Peter Mathieson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : Injections of subtoxic doses of HgCl2 (mercuric chloride) cause a systemic autoimmune disease in genetically predisposed rats and mice. My work was designed to elucidate how HgCl2 induces lymphocyte activation and how the response to HgCl2 is regulated in susceptible and resistant strains. LÄS MER

  3. 7. Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes

    Författare :Cheng-Hong Wei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this study is to investigate the role of the affinity of peptide:MHC/TCR interaction in the regulation of T cell activation, death and repertoire selection. Three aspects pertinent for our understanding of this issue have been analyzed. LÄS MER

  4. 8. Structural analyses of immune cell receptor signalling and activation

    Författare :Maria Saline; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; structural biology; NMR; protein-protein interaction; immunology;

    Sammanfattning : Structural biology is a scientific field where the aim is to observe macromolecules on a atomic level to understand their functions. Often these macromolecules are proteins that make, almost, everything happen within the cells; from hormones and enzymes to building blocks and controlling gene expression. LÄS MER

  5. 9. Chronic immune activation and lymphocyte apoptosis during HIV-1 infection

    Författare :Nicolas Ruffin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 infected individuals are subject to a chronic immune activation resulting from HIV-1 replication, microbial translocation, and lymphopenia. Despite the great advance of antiretroviral treatment (ART), the immune activation remains associated with poor immune reconstitution during HIV-1 infection. LÄS MER

  7. 10. Human natural killer cell activation and differentiation in health and viral infection

    Författare :Niklas Björkström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are lymphocytes that belong to the innate immune system. They are important for the early defense against viral infections and provide tumor Immune surveillance against both solid tumors and leukemias as well as in settings of hematopoietic stem cell transplantation. LÄS MER