Sökning: "T-cell clone"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden T-cell clone.

  1. 1. T cell antigen receptor usage, phenotype and cytokine production in human diseases

    Författare :Jan Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T cell; T cell receptor; T cell expansion; phenotype; cytokine; extrinsic allergic alveolitis; allergic asthma; multiple myeloma; Wegener s granulomatosis; sarcoidosis;

    Sammanfattning : T lymphocytes are of critical importance for initiating and controlling immune responses, as the T cell receptor (TCR) for antigen allows a highly specific antigen recognition. Determination of TCR usage and characterization of T cell subsets in different diseases helps us understand the underlying immunopathogenic mechanisms, and may also lead to the development of new therapeutic approaches. LÄS MER

  3. 2. T cell dependent B lymphocyte activation, growth and maturation : the role of lymphokines

    Författare :Sven Pettersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TH cell activated B- cell growth maturation B-cell growth factor BSF-pI B-cel1 maturation factor s BMA neonatal B-cell prol iferation anti body secretion;

    Sammanfattning : The present work concerns the regulation of B cell activation, growth and terminal differentiation of helper T cells.T cell dependent (TD) B cell activation requires physical cell to cell contact between competent helper T cells (TH) and B cells and the recognition of MHC Class II antigens. LÄS MER

  4. 3. Dust mite allergens : cloning, characterisation and T-cell responses

    Författare :Tove L J Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The number of allergens that have been cloned has increased dramatically during the last 10 years, and today, over 400 allergen sequences are available in the databases. In addition, at least 15 dust mite allergens have been characterised. LÄS MER

  5. 4. Targets for immune mediated killing of tumor cells and T cell functions in B-CLL

    Författare :Eva D Rossmann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chronic lymphocytic leukemia; apoptosis; monoclonal antibody therapy; quantitative flow cytometry; cytokines; T cell dysfunctions;

    Sammanfattning : There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of enhanced control over the malignant clone. LÄS MER

  7. 5. Recognition by and escape from CD8+ T cell immune surveillance in cancer bearing hosts

    Författare :Koji Kono; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : CD8+ T cells ( TCD8+ ) can specifically recognize tumor cells through MHC class I molecules associated with peptides that are 8-l0 amino acid residues long. In recent years, a number of tumor-associated antigens, or their epitopes, have been identified and characterized with the advent of new methods in molecular biology and in peptide isolation. LÄS MER