Sökning: "Specialized pro-resolving mediators"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Specialized pro-resolving mediators.

  1. 1. Endogenous and microbial modulators of inflammation

    Författare :Jamie D. Kraft; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; Resolution; Specialized pro-resolving mediators; Lipoxins; Neutrophils; Cardiometabolic disease; Next-generation probiotic; Oxygen-tolerance; Faecalibacterium prausnitzii; Desulfovibrio piger; Inter-strain variation;

    Sammanfattning : Cardiometabolic disease is characterized by dysregulated, chronic inflammation, that may result from impaired resolution pathways or alterations in the gut microbiota. Thus, restoring specialized pro-resolving mediators (SPMs) or intestinal bacteria with immunomodulatory properties represent potential therapeutic strategies for patients. LÄS MER

  3. 2. Resolution of inflammation as a therapeutic target for Alzheimer’s disease

    Författare :Mingqin Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, clinically manifested by memory impairment, loss of ability in conducting daily activity and increased need for care, thus causing immense suffering for the afflicted and relatives, as well as a huge economic burden to the society. Despite the existence of symptom-relieving drugs, there is no drug that can stop the progression or cure the disease. LÄS MER

  4. 3. The role of the G protein-coupled receptor ChemR23 in cardiovascular inflammation

    Författare :Gonzalo Artiach Castañón; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular inflammation is a biological process characterized by the immune cell response to harmful stimuli within the cardiovascular system, wherein homeostasis is reestablished by neutralizing the insult and promoting the repair of the damaged tissue. However, a failure in the resolution of inflammation can lead to a maladaptive inflammatory response, contributing to the development of cardiovascular diseases such as aortic valve stenosis (AVS) and atherosclerosis, as well as vascular complications such as intimal hyperplasia. LÄS MER

  5. 4. Resolution of inflammation in Alzheimer’s disease

    Författare :Xiuzhe Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation is associated with Alzheimer’s disease (AD), a neurodegenerative disorder with no cure up to date. Ample evidence from studies within various disciplines support that inflammation plays a role in AD. LÄS MER

  7. 5. Understanding inflammation requires neuroscience

    Författare :Alessandro Gallina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation and its resolution are processes subject to neural regulation (1). The best-characterized immune-regulating reflex is the “inflammatory reflex”, in which the efferent branch of the vagus nerve plays a central role in regulating cytokine-release in the periphery. LÄS MER