Sökning: "SR 120107A"

Hittade 1 avhandling innehållade orden SR 120107A.

1. 1. Neuropeptide Y Y1 receptor mechanisms in sympathetic vascular control

   Författare :Rickard E Malmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Sympathetic vasoconstriction; neuropeptide Y1 Y; receptor antagonists; BIBP 3226; SR 120107A; ischaemia; pig.;

   Sammanfattning : It was demonstrated that the Y1 receptor was the predominant vascular neuropeptide Y (NPY) receptor in pig kidney and hind limb as exogenous and endogenous NPY evoked vasoconstrictor responses that were almost or totally abolished by the selective non-peptide Y1 receptor antagonist, BIBP 3226. Furthermore, renal vasoconstriction was evoked by NPY and a peptide Y1 agonist, but not by a Y 2 agonist, and these responses were strongly reduced by another non-peptide Y, receptor antagonist, SR 120107A. LÄS MER