Sökning: "SFV"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet SFV.

  1. 1. Glucosyl transferase gene(s) of temperate bacteriophages SfX and SfV and their role in the modification of the O-antigen of Shigella flexneri

    Författare :Pham Thi Huan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Shigella flexneri is the main cause of bacillary dysentery in developing countries with a high attack rate and mortality in young children. Thus developing a S. flexneri vaccine has been given priority by WHO. It has been documented that Shigella lipopolysaccharide (LPS) is highly immunogenic. LÄS MER

  3. 2. The dynamic envelope of a fusion class II virus : molecular reorganizations during prefusion stages of Semliki forest virus

    Författare :Lars Haag; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alphavirus; SFV; fusion; cryo-EM; formaldehyde; reorganization; cross-link; 3D reconstruction; acid pH; Pepscan; MAb; inactivation; dissociation; monoclonal antibody;

    Sammanfattning : The aim of this study was to explore a membrane fusion mechanism, prevailing in alphaviruses and known as virus class 11 fusion. The model virus for this mechanism is Semliki Forest virus (SFV) of the alphavirus family. LÄS MER

  4. 3. Regulation of autophagy and mTOR during Semliki Forest virus infection

    Författare :Kai Eng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Semliki Forest virus (SFV) infection causes dramatic changes to the infected cell. For example, synthesis of most cellular proteins shuts off within 4 hours. The cell launches an antiviral response, forms stress granules and, as we found in the work leading up to this thesis, accumulates autophagosomes. LÄS MER

  5. 4. Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway

    Författare :Lifeng Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular responses and help to identify potential targets for therapeutic intervention. LÄS MER

  7. 5. Induction of type I interferons and viral immunity

    Författare :Åsa Hidmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Virus-induced type I interferons (IFNα/β) are key mediators of innate immunity and important modulators of adaptive immunity. Early recognition of virus and induction of IFNα/β are important for limiting the spread of the virus. LÄS MER