Avancerad sökning

Hittade 1 avhandling som matchar ovanstående sökkriterier.

1. 1. Regulation of insulin-like growth factor-1 receptor expression and signaling

   Författare :Radu Vasilcanu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; â-arrestins; MDM2; ubiquitination; internalization;

   Sammanfattning : Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin receptor tyrosine kinase family is a broadly expressed transmembrane receptor that plays a key role in malignant cell growth. IGF-1R transmits information provided by extracellular stimuli into intracellular signaling pathways resulting in the subsequent regulation of various effector systems. LÄS MER