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Visar resultat 6 - 10 av 25 avhandlingar som matchar ovanstående sökkriterier.
6. Regulation of protein degradation by virus derived repeated amino acid sequences
Sammanfattning : The ubiquitin-proteasome pathway plays a central role in the controlled degradation of short-lived and regulatory proteins important m a variety of cellular processes, including antigen presentation and combating viral infections. The presentation of antigenic peptides derived from ubiquitin-proteasome dependent degradation of vital proteins to MHC class I restricted cytotoxic T cells is a central component of antiviral responses. LÄS MER
7. The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease
Sammanfattning : Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. LÄS MER
8. Intensive care Muscle Wasting and Weakness : Underlying Mechanisms, Muscle Specific Differences and a Specific Intervention Strategy
Sammanfattning : The intensive care unit (ICU) condition, i.e., immobilisation, sedation and mechanical ventilation, often results in severe muscle wasting and weakness as well as a specific acquired myopathy, i.e. LÄS MER
9. Dendritic cell interactions with Gram negative bacteria
Sammanfattning : The interaction between murine bone marrow-derived dendritic cells (DC) and the Gram negative bacteria Salmonella typhimurium and Escherichia coli have been characterised. These studies showed that DC phagocytosed and processed S. typhimurium and E. LÄS MER
10. Old-age muscle atrophy : cellular mechanisms and behavioral consequenses
Sammanfattning : With advancing age, humans and rodents alike lose about one third of the skeletal muscle mass. A process referred to as old-age muscle atrophy or sarcopenia. LÄS MER
