Sökning: "Perforin"

Visar resultat 6 - 10 av 47 avhandlingar innehållade ordet Perforin.

  1. 6. Studies on cytokine mRNA expression in mononuclear cells in neuroimmunological diseases

    Författare :Darius Matusevicius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), characterized by perivascular accumulation of blood mononuclear cells (MNC) and patchy demyelination. High levels of circulating myelin antigen specific T and B cells, with an accumulation in cerebrospinal fluid (CSF), suggest the involvement of cytokines in the pathogenesis of MS. LÄS MER

  3. 7. Studies on the cytokine network in multiple sclerosis

    Författare :Pia Kivisäkk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is considered to be an inflammatory immune-mediated disease of the central nervous system (CNS), the aetiology of which remains enigmatic. Cytokines produced by infiltrating inflammatory cells and resident cells in the brain are proposed to play a major role in directing and regulating the immune response, as well as mediating tissue damage. LÄS MER

  4. 8. T cells in solid tumors : investigating the immunomodulation in the tumor microenvironment

    Författare :Ciputra Adijaya Hartana; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system protects human from cancer through an immunosurveillance mechanism. However, the progressive nature of tumor cells to differentiate and the complexity of the tumor microenvironment may result in the immunomodulation of immune cells. LÄS MER

  5. 9. Local immune responses in tuberculosis : cytolytic effector functions at the site of mycobacterium tuberculosis infection

    Författare :Sayma Rahman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite recent advances in tuberculosis (TB) research, shortage of knowledge still exists that limits the host-pathogen interactions in human TB. Cell-mediated immunity has been shown to confer protection in TB, although the relative importance of cytolytic T cells (CTLs) expressing granule-associated effector molecules perforin and granulysin is debated. LÄS MER

  7. 10. HIV-1 immune responses induced by natural infection or immunisation

    Författare :Lindvi Gudmundsdotter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The development of an effective HIV-1 vaccine must be considered as one of today s greatest biomedical goals and challenges. The nature of the HIV-1 virus, characterised by its tropism for the CD4+ T cells of the immune system and its integration into the host genome, together with the vast viral variability, allows the HIV-1 virus to establish a latent infection and evade the host defence mechanisms. LÄS MER