Sökning: "Pdx1"

Visar resultat 16 - 17 av 17 avhandlingar innehållade ordet Pdx1.

  1. 16. Role of PAK4 in pancreas development and breast cancer

    Författare :Miao Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : PAK4 is a Rho GTPase-regulated serine/threonine kinase that possesses critical functions in embryonic, neuronal and vascular development, immune defense and cancer. Constitutive PAK4 depletion causes embryonic lethality and mice with conditional PAK4 gene depletion in the heart and in the central nervous system displayed serious organ defects. LÄS MER

  3. 17. Apolipoprotein A-I in glucose metabolism and amyloidosis

    Författare :Oktawia Nilsson; Medicinsk proteinvetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; Apolipoprotein A-I; beta cell; cardiovascular disease; cholesterol efflux; diabetes; glucose metabolism; glycation; high-density lipoprotein; insulin secretion;

    Sammanfattning : The role of Apolipoprotein A-I (ApoA-I), the main protein component of HDL, in cholesterol transport and metabolism is well known and has been studied for more than four decades. More recently, ApoA-I protein has been shown to also have a positive role in glucose control by both stimulation of glucose uptake by muscles and by increasing glucose-stimulated pancreatic insulin secretion. LÄS MER