Sökning: "Apolipoprotein A-I"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Apolipoprotein A-I.

  1. 1. Apolipoprotein A-I in glucose metabolism and amyloidosis

    Författare :Oktawia Nilsson; Medicinsk proteinvetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; Apolipoprotein A-I; beta cell; cardiovascular disease; cholesterol efflux; diabetes; glucose metabolism; glycation; high-density lipoprotein; insulin secretion;

    Sammanfattning : The role of Apolipoprotein A-I (ApoA-I), the main protein component of HDL, in cholesterol transport and metabolism is well known and has been studied for more than four decades. More recently, ApoA-I protein has been shown to also have a positive role in glucose control by both stimulation of glucose uptake by muscles and by increasing glucose-stimulated pancreatic insulin secretion. LÄS MER

  3. 2. Biophysical Studies of Apolipoprotein A-IM and a Partitioning study

    Författare :Malin Suurkuusk; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apolipoprotein A-IMilano; Apolipoprotein A-I; Lipoprotein; Lipid; Microcalorimetry; DCS; Denaturation; Guanidine Hydrochloride; Physics; Fysik; Chemistry; Kemi;

    Sammanfattning : The major part of this thesis deals with the similarities and differences in some biophysical properties of apolipoprotein A-I (apo A-I) and the molecular variant apolipoprotein A-IMilano (apo A-IM), and the influence on lipid binding. A model compound partitioning study has also been performed. LÄS MER

  4. 3. Studies on the assembly and secretion of apolipoprotein B containing lipoproteins

    Författare :Karin Lindberg; Göteborgs universitet; []
    Nyckelord :apolipoprotein B; lipoprotein; lipoprotein biosynthesis; Brefeldin A; microsomal triglyceride transfer protein; liver fatty acid binding protein;

    Sammanfattning : Lipoproteins are water-soluble particles of lipids and proteins, which deliver water-insoluble lipids from intestine or liver to target tissues where the lipids are used as fuel or storage. Lipoproteins consist of a core of hydrophobic lipids surrounded by an amphipatic monolayer of polar lipids and specific proteins, apolipoproteins. LÄS MER

  5. 4. Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models

    Författare :Maria Skoog; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Lipid; ACTH; Apolipoprotein-B; Cholesterol; Human; Rat; Rabbit; Medicin människa och djur ;

    Sammanfattning : Abstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. LÄS MER

  7. 5. Aspects of the regulation of human sperm motility

    Författare :Pär K G Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis I address some of the possible causes for oligozoospermia and low sperm motility, two factors that, singly or in combination, are often seen in cases of male subfertility. In the first study we evaluated the effect on human spermatozoa of the toxicity of compounds present in diesel exhaust. LÄS MER