Sökning: "PD-L1"

Visar resultat 36 - 40 av 45 avhandlingar innehållade ordet PD-L1.

  1. 36. Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer

    Författare :Esther Schoutrop; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR T cells and remarkable clinical response rates have been achieved with second generation CD19-directed CAR T cells containing either a CD28 or 4-1BB co-stimulatory domain for the treatment of B cell malignancies. LÄS MER

  3. 37. Sarcoma ecosystems : spatial characterization and prognostic significance

    Författare :Yanhong Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. LÄS MER

  4. 38. Studies of innate and adaptive lymphocytes in human liver diseases and viral infections

    Författare :Christine Lea Zimmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system, including innate and adaptive lymphocytes, is involved in determining the outcome of many human diseases. Two lymphocyte subsets, natural killer (NK) cells and T cells, which are present in both peripheral blood and in tissues, will be further discussed in the context of acute and chronic viral infections and inflammatory liver diseases in this thesis. LÄS MER

  5. 39. Immunoregulatory effects of placenta-derived decidual stromal cells

    Författare :Tom Erkers; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Decidual stromal cells (DSCs) play a pivotal role in feto-maternal tolerance to prevent rejection of the fetus during pregnancy. This provides a rationale for immunomodulatory stromal cells from the placenta being isolated and used as cellular therapy for inflammatory conditions following hematopoietic stem cell transplantation (HSCT). LÄS MER

  7. 40. Revealing the secrets of MARCO : a target for cancer immunotherapy

    Författare :Silke Eisinger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. Cancer is still one of the leading causes for death worldwide and inflammation became one of the hallmarks of cancer. LÄS MER