Sökning: "Pádraig D arcy"

Hittade 2 avhandlingar innehållade orden Pádraig D arcy.

1. 1. Identifying Essential Deubiquitinase Interactions and Targeting Protein Ubiquitination in Cancer

   Författare :Johannes Gubat; Padraig D´arcy; Stig Linder; Maria Turkina; Per Lindahl; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Deubiquitinase; b-AP15; Ubiquitin-proteasome system;

   Sammanfattning : Cancer is the second leading cause of death globally and is one of the most pressing health issues today. While significant advances have been made in cancer treatment, drug resistance and toxicity remain formidable obstacles to successful therapy. Thus, there is a need to find novel targets that pave the way for new cancer therapeutics. LÄS MER

3. 2. Proteasome Inhibitors against Cancer: Determining Biology and Finding Novel Compounds

   Författare :Arjan Mofers; Stig Linder; Padraig D´arcy; Sonia Lain; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Cancer continues to be a tremendous burden on society in terms of loss of quality of life and life-years. The ubiquitin proteasome system (UPS), responsible for the bulk of protein turnover in the cell, is considered an attractive target in cancer therapy. LÄS MER