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Visar resultat 1 - 5 av 14 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Catalytic Properties and Tissue Distribution of Cytochrome P450 4F8 and 4F12 : Expression of CYP4F8 in Eye Tissues and Psoriatic Lesions

    Författare :Katarina Stark; Ernst H Oliw; Leif Bertilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Arachidonic acid metabolism; Cytochrome P450; 19-Hydroxyprostaglandins; Immunohistochemistry; Ocular tissues; Psoriasis; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

    Sammanfattning : The human cytochrome P450 (CYP) family of monooxygenases is important for metabolism of drugs and endogenous compounds, e.g., vitamin A and D, cholesterol, steroids, fatty acids, and eicosanoids. This thesis describes the tissue distribution, catalytic properties, and possible function of CYP4F8 and CYP4F12. LÄS MER

  3. 2. Matrix metalloproteinases and their inhibitors in ocular neovascularization

    Författare :Björn Steén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; Neovascularization; Retina; Bruch membrane; Cornea; MMP; TIMP; VEGF; In situ hybridization.;

    Sammanfattning : Growth of pathological new vessels (angiogenesis) in the eye is a leading cause of severe vision-loss. Ocular angiogenesis is seen in the anterior part of the eye as in corneal neovascularization, or in the posterior part as in diabetic retinopathy, retinopathy of prematurity or age-related macular degeneration. LÄS MER

  4. 3. Biomechanics of the Human Eye and Intraocular Pressure Measurements

    Författare :Darja Ljubimova; Anders Eriksson; Anders Eklund; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; IOP; GAT; ocular biomechanics; corneoscleral envelope; finite element modelling; parametric analysis; Engineering mechanics; Teknisk mekanik;

    Sammanfattning : This thesis addresses the reliability of Goldmann-type applanation tonometers (GAT). It deals with the investigation of the relation between predicted intraocular pressure, IOPG and true pressure, IOPT. LÄS MER

  5. 4. Retinol dehydrogenases in retinoid metabolism : studies on a 9-cis/11-cis-retinol dehydrogenase in adult and embryonic tissues

    Författare :Anna Romert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Retinoids (vitamin A derivatives) are necessary for normal embryonic development and in the adult, for vision, differentiation of various epithelia, reproduction and in the immune system. The physiological effects of retinoids are mediated by binding to the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). LÄS MER

  7. 5. Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation

    Författare :David Hallberg; Göteborgs universitet; []
    Nyckelord :Myofibroblast; Polyploid; Allogeneic; Graft-versus-Host Disease;

    Sammanfattning : Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is that the immune effector cells in the graft may become activated towards the host´s healthy tissues, resulting in a condition called Graft-versus-Host Disease (GvHD). LÄS MER