Sökning: "NRP1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet NRP1.

  1. 1. Regulation of VEGFR2 signaling in angiogenesis and vascular permeability

    Författare :Chiara Testini; Lena Claesson-Welsh; Mats Hellström; Mauro Giacca; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; VEGFR2; angiogenesis; permeability; NRP1; Y949; Y1212; paladin; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Angiogenesis and vascular permeability occur in physiological and pathological conditions. Angiogenesis denotes the process of blood vessel formation from preexisting quiescent vessels. LÄS MER

  3. 2. Neuropilin-1 regulation of tumor vascularization and growth

    Författare :Eric Morin; Lena Claesson-Welsh; Hellmut Augustin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Neuropilin-1; VEGFR2; tumor biology; pancreatic ductal adenocarcinoma; renal cell carcinoma; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Angiogenesis, the formation of new blood vessels from existing ones, is dysregulated during tumor progression as a result of chronic hypoxia and inflammation. Such alterations lead to a lack of vessel hierarchy, and the formation of poorly perfused, leaky and blunt-ended vessels, contributing to disease progression. LÄS MER

  4. 3. VEGFR-2 in Endothelial Differentiation and Vascular Organization

    Författare :Dan Edholm; Lena Claesson-Welsh; Xiujuan Li; Victoria Bautch; Uppsala universitet; []
    Nyckelord :Molecular medicine; Embryonic stem; VEGFR-2; Flk1; KDR; VEGF; vasculogenesis; angiogenesis; embryoid body; Molekylärmedicin;

    Sammanfattning : The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. LÄS MER

  5. 4. Studies in nuclear receptor Nurr1 : identification of Nurr1-regulated genes

    Författare :Elisabet Hermanson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor family comprises more than sixty members, including receptors for steroids, thyroid hormone and retinoids. Many nuclear receptors function as ligand- activated transcription factors that regulate the expression of specific target genes. LÄS MER

  7. 5. Exploring the role of PDGF-D in health and disease

    Författare :Hanna Gladh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The platelet-derived growth factors (PDGF) and their receptors (PDGFRs) regulate growth and migration in cell populations of mesenchymal origin. The PDGF signaling system is vital for development, in neural crest formation, in organogenesis, and in maturation of the microvasculature. In the adult, PDGFs are needed to maintain homeostasis. LÄS MER