Sökning: "Mohammad Reza Rezvany"

Hittade 1 avhandling innehållade orden Mohammad Reza Rezvany.

1. 1. Natural specific T cell immunity in patients with B-cell chronic lymphocytic leukaemia (B-CLL) : (A clinical and immunological study)

   Författare :Mohammad Reza Rezvany; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :B-CLL; TCR usage; clonality; natural T cell immunity; costimulatory molecules; dendritic cells; cytokines; tumor derived VH-CDR3.;

   Sammanfattning : Analysis of TCRBV (T-cell receptor B variable) gene usage of the T cell repertoire in patients with B cell chronic lymphocytic leukaemia (B-CLL) and age-matched healthy control donors showed that major perturbations were more frequently seen in the CD4+ T cell subset than in CD8 population. Analysis of the CDR3 length polymorphism revealed a significantly higher degree of clonality within the CD4+ and CD8+ T cell repertoire of patients as compared to the normal control population. LÄS MER