Sökning: "costimulatory molecules"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden costimulatory molecules.

1. 1. Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88

   Författare :Malin Sundquist; Göteborgs universitet; []
   Nyckelord :Dendritic cells; Costimulatory molecules; Bacterial infection; Pro-inflammatory cytokines; Toll-like receptors; Ag presentation; Cell death;

   Sammanfattning : The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during Salmonella infection. LÄS MER

3. 2. T cells and costimulatory factors in myasthenia gravis

   Författare :Maria Kakoulidou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T cells; Myasthenia gravis MG ; costimulation; autoimmune disease; genetic polymorphism; twin;

   Sammanfattning : The autoimmune disease myasthenia gravis (MG) is characterized by muscle weakness due to a loss of acetylcholine receptors (AChR) at the neuromuscular end plate. Most MG patients have pathogenic antibodies directed against the receptor. We provide further evidence that T cells are important for establishment and continuation of the disease. LÄS MER

4. 3. Triggering and inhibitory molecules affecting target cell recognition by NK cells

   Författare :Margarita Salcedo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NK cell; MHC class 1; NKinhibitory receptors; costimulatory molecules ISBN 9 1-628-2643-3;

   Sammanfattning : NK cells were described originally for their ability to lyse certain tumor cell lines without prior immunization. MHC class I molecules have been shown to deliver a negative signal to NK cells preventing killing of target cells. This reaction is mediated via specific receptors on NK cells, referred to as KIR in man and Ly49 in mouse. LÄS MER

5. 4. The ups and downs of T cells The role of costimulatory molecules in the modulation of T cell responses

   Författare :Christina Olsson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; CD28; costimulation; CD152; IL-2; NF-kB; AP-1; superantigen; Immunology; T cell; serologi;

   Sammanfattning : T cell activation requires the combination of antigen in the context of MHC and costimulatory molecules to induce a functional immune response. For our studies, we primarily utilized superantigens (SAg) that bind MHC class II molecules as first signal. LÄS MER

7. 5. Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders

   Författare :Priya Sakthivel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Co‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). LÄS MER