Sökning: "MGST1"

Visar resultat 6 - 10 av 14 avhandlingar innehållade ordet MGST1.

  1. 6. Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism

    Författare :Linda Spahiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is a family of six membrane bound proteins with different biological functions. MAPEG superfamily members enable and catalyze reactions where reactive lipid intermediates are either transformed to physiological messengers or turned into unreactive compounds. LÄS MER

  3. 7. Genetic variation and regulation of oxidative stress related genes

    Författare :Lena Forsberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxidative stress, is a state that has been implicated in the pathogenesis of a variety of human diseases, including atherosclerosis, inflammation, neurodegenerative disease and cancer. In an effort to determine the importance of oxidative stress in disease etiology, by a genetic approach, we have, studied individual variation and regulation of oxidative stress related genes including also basal characterization. LÄS MER

  4. 8. Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1

    Författare :Staffan Thorén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. LÄS MER

  5. 9. Microsomal glutathione transferase : studies on the kinetic mechanism, species variety, binding properties and substrate measurement

    Författare :Tie-Hua Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microsomal glutathione transferase (MGST) is a membrane bound detoxification enzyme, which has been purified from different species including rat, mouse, human, frog, and fish. The rat MGST1 is localized predominantly in the liver microsomes and the outer mitochondrial membrane. LÄS MER

  7. 10. Mechanism of enzymes involved in leukotriene C4 biosynthesis

    Författare :H R Shabbir Ahmad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cysteinyl leukotrienes (cys-LTs) are potent proinflammatory mediators associated with various diseases including asthma and allergic rhinitis. Leukotriene C4 synthase (LTC4S) and microsomal glutathione transferase 2 (MGST2) catalyze conjugation of the epoxide intermediate LTA4 with GSH to form LTC4, the parent compound of the cys-LTs. LÄS MER