Sökning: "MAPK- and AMPK-signaling pathways"

Hittade 2 avhandlingar innehållade orden MAPK- and AMPK-signaling pathways.

  1. 1. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

    Författare :Mei Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

    Sammanfattning : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. LÄS MER

  3. 2. Kinase cascades in the regulation of glucose homeostasis

    Författare :Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Sammanfattning : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. LÄS MER