Sökning: "MAPK cascades"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden MAPK cascades.

  1. 1. Kinase cascades in the regulation of glucose homeostasis

    Författare :Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Sammanfattning : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. LÄS MER

  3. 2. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

    Författare :Mei Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

    Sammanfattning : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. LÄS MER

  4. 3. Role of Rck2 in metal and oxidative stress responses

    Författare :Swarna Swaminathan; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Yeast cells respond to rapid and drastic changes in their environment by activating signal transduction cascades that perform specific functions depending on the type of stress caused. MAP kinase pathways are one such network of protein kinases that result in the induction of transcription factors and a plethora of transcriptional and translational events leading to stress response. LÄS MER

  5. 4. Studies on antidepressant-mediated regulation of signal transduction

    Författare :Hongshi Qi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression affects around 16% of the population at some point in their lives and major depressive disorder is a leading cause of disability worldwide. Depression is caused by an interaction of genetic and environmental factors, but the molecular and cellular mechanisms underlying its pathogenesis are not entirely clear. LÄS MER

  7. 5. The many faces of IGF-1R from cell surface to the nucleus

    Författare :Sandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. LÄS MER