Sökning: "Lipidomics"

Visar resultat 16 - 19 av 19 avhandlingar innehållade ordet Lipidomics.

  1. 16. Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease

    Författare :Ibrahim Kaya; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Lipids; Amyloid plaques; Mass spectrometry imaging; MALDI; Trimodal MALDI; Static MALDI; Dual polarity MALDI-MSI on the same pixel points; Neurodegeneration; Immunopathology; Amyloid peptides; APOE; Myelin; Sulfatides; 5xFAD; tgSwe; tgArcSwe; APP;

    Sammanfattning : Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. LÄS MER

  3. 17. Membrane Fluidity Regulation: From C. elegans to mammalian cells

    Författare :Ranjan Devkota; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PAQR-2; adiponectin receptors; IGLR-2; saturated fats; membrane fluidity; fatty acid desaturation; unsaturated fatty acid; membrane homeostasis;

    Sammanfattning : Biological membranes are primarily an assembly of lipids and proteins. Collectively, these constituents within a phospholipid bilayer determine the physical membrane properties such as fluidity, viscosity, thickness, packing and permeability. Maintenance of membrane properties within acceptable margins, i.e. LÄS MER

  4. 18. Bridging the gap between lipid dyshomeostasis and brain disorders : role of prosaposin and progranulin

    Författare :Yachao He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Brain tissue is the second-highest lipid-containing tissue after adipose in the human body. Lipid homeostasis maintenance requires the coordination of multiple cellular organelles. Pathogenesis of brain disorders, especially Parkinson’s disease (PD), usually involves different dysfunctional pathways that intimately link to lipid homeostasis. LÄS MER

  5. 19. An integrative systems biology study to understand immune aging in people living with HIV

    Författare :Flora Mikaeloff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antiretroviral therapy (ART) reduces viral replication, restores T helper cells and improves the survival of people living with HIV (PWH), transforming a life-threatening disease into a manageable chronic infection. Nevertheless, PWH under ART shows aging-related diseases such as bone abnormalities, non-HIV-associated cancers, and cardiovascular and neurocognitive diseases. LÄS MER