Sökning: "HPA axis"

Visar resultat 21 - 25 av 76 avhandlingar innehållade orden HPA axis.

  1. 21. Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma

    Författare :Yeasmin Tahera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HPA axis; corticosterone; glucocorticoid receptor; NFêB; spiral ganglion neurons; cochlea; acoustic trauma; paraventricular nucleus;

    Sammanfattning : The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several physiological systems including the auditory system. LÄS MER

  3. 22. Gene-environment interactions between HPA axis regulatory genes and stressful life events in suicide attempts

    Författare :Yair Jacob Ben-Efraim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Suicide is a leading cause of death. In the future, treatment for suicidal behavior, as well as public health prevention and/or intervention efforts, may be guided by genetic epidemiology. This research is informed by biological alterations which have been previously observed in suicidal behavior. LÄS MER

  4. 23. Altering the fetal programming of the HPA axis and the consequences in the adult auditory system

    Författare :Amzad Hossain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prenatal glueocorticoid (GC) has been associated with a variety of alterations in the adult offspring. Hypothalamo-Pituitary-Adrenal (HPA) axis, which is the key regulator for almost all kind of neuroendocine function and behavior, is highly susceptible to prenatal exposure to excess GC during development. LÄS MER

  5. 24. Examining Female Resilience to Early Environmental Influences : Short- and long-term consequences on behaviour, HPA axis activity and alcohol intake after prolonged maternal separation

    Författare :Stina Lundberg; Erika Roman; Ingrid Nylander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adolescence; Adulthood; Corticosterone; Early-life stress; Handling; Maternal deprivation; Multivariate concentric square field; MCSF; Sex differences; Social play behavior; Stress reactivity; Supplier differences; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Early-life experiences are an important factor influencing further development of the individual. Adverse experiences early in life, such as various kinds of abuse or neglect, are types of early-life stress that can adversely affect an individuals health, as well as contribute to the development of an array of disorders later in life. LÄS MER

  7. 25. The HPA axis in type 2 diabetes : some aspects in relation to insulin sensitivity, beta-cell function and IGF-I/IGFBP-1

    Författare :Lisa Arnetz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes (T2D) is characterized by insulin resistance and β-cell failure, abdominal obesity, hypertension and dyslipidemia. These symptoms are also characteristic of states of hypercortisolism. LÄS MER