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Visar resultat 11 - 15 av 28 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. The role of glycoproteins in glomerular pathophysiology

    Författare :Alina Khramova; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteoglycans; Extracellular matrix; IgA nephropathy; Diabetic kidney disease;

    Sammanfattning : Chronic kidney disease (CKD) is increasing worldwide and has a prevalence of around 10%. With time patients are at risk of losing their renal function and will need dialysis or transplantation for survival. There are no specific treatments available and mechanisms behind the onset and progression of CKD are still not fully investigated. LÄS MER

  3. 12. Putting the pieces together : elucidation of podocyte biology in the homeostasis of the kidney filtration barrier

    Författare :Patricia M Rodriguez Rivera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : End-stage renal disease (ESRD) is a devastating condition that can only be treated with chronic dialysis or kidney transplantation. ESRD treatment costs account for up to 10% of healthcare budgets in the Western world. The 5-year survival for patients in dialysis is only about 40%. Glomerular disease processes are the main cause of ESRD. LÄS MER

  4. 13. Characterization of novel glomerular proteins : role in physiology and disease

    Författare :Ann-Charlotte Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy. The costs for treatment of CKD represent an enormous burden to the health care system. LÄS MER

  5. 14. Characterization of novel genes of importance for renal glomerular function and disease

    Författare :Ásmundur Oddsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :kidney glomerulus;

    Sammanfattning : Glomerular kidney diseases are a major health care burden. The glomerular filtration barrier consists of three layers: the slit diaphragm that bridges the interlocking foot pro- cesses of the podocytes, the glomerular basement membrane and fenestrated endothelial cells. LÄS MER

  7. 15. Role of new podocyte-associated proteins in the renal ultrafiltration barrier

    Författare :Angelina Schwarz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. LÄS MER