Sökning: "Geoffrey Tucker"

Hittade 1 avhandling innehållade orden Geoffrey Tucker.

1. 1. Involvement of Membrane Transport Proteins in Intestinal Absorption and Hepatic Disposition of Drugs Using Fexofenadine as a Model Drug

   Författare :Niclas Petri; Hans Lennernäs; Geoffrey Tucker; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Fexofenadine; OATP; P-glycoprotein; Organic Anion Transporters; ATP-Binding Cassette Transporters; membrane transport proteins; Bioavailability; Biopharmaceutics; Biofarmaci; Biopharmacy; Biofarmaci;

   Sammanfattning : The aims of this thesis were to study the in vivo relevance of membrane transporters for intestinal absorption and the hepatic disposition of drugs in humans and preclinical models. Fexofenadine is a substrate for ABCB1 (P-glycoprotein) and members of the organic anion transporting polypeptide (OATP/SLCO) family. LÄS MER