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1. 1. Factors influencing the metabolism of inorganic arsenic in humans

   Författare :Anna-Lena Lindberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Arsenic; AS3MT; Gender differences; GSTO1; Metabolism; Methylation; MTHFR; Nutrition; Polymorphisms;

   Sammanfattning : Inorganic arsenic (iAs), a naturally occurring drinking water contaminant, is a potent human carcinogen and toxicant. It is believed that in humans, as well as in most mammals, inorganic arsenic is biotransformed via reduction and methylation using one-carbon metabolism with S-adenosyl methionine (SAM) as methyl donor, and is excreted mainly in urine as dimethylarsinate (DMA) and methylarsonate (MA) as well as some unmethylated iAs (arsenate (As(V)) and arsenite (As(III)). LÄS MER