Sökning: "FK506"

Visar resultat 11 - 13 av 13 avhandlingar innehållade ordet FK506.

  1. 11. Regulation of T cell apoptosis by calcium and zinc ions

    Författare :Shunai Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Apoptosis is a major form of cell death involved in fundamental processes in the mammalian immune system. Although extensive studies have been carried out to explore the mechanisms involved in lymphocyte apoptosis, a defined signaling pathway is still unclear. LÄS MER

  3. 12. Novel mechanisms of glucocorticoid-induced insulin resistance in human adipose tissue

    Författare :Cherno Omar Sidibeh; Jan Eriksson; Maria João Pereira; Anna Krook; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid receptor type 1 fkbp51 dexamethasone type 2 diabetes adipocytes; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The global prevalence of obesity and type 2 diabetes (T2D) is increasing. From a public health perspective, it is therefore of interest to identify common underlying mechanisms of these comorbidities. Glucocorticoids are steroid hormones that are important in stress regulation in mammals. LÄS MER

  4. 13. Pharmacological and genetic manipulation of adipose cell differentiation and metabolism

    Författare :Milica Vranic; Maria J. Pereira; Jan Eriksson; Niklas Mejhert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; adipocyte; type 2 diabetes; CRISP Cas9; FKBP51; CDKN2C; second-generation antipsychotics; glucocorticoids; dopamine; dopamine receptor;

    Sammanfattning : Adipose tissue dysfunction has a pivotal role in the development of obesity and related metabolic complications, such as insulin resistance, cardiovascular disease, and diabetes. The overall aim was to study the consequences of adipose exposure to pharmacological agents, as well as dysregulations in the expression of genes, potentially involved in adipose tissue dysfunction and related metabolic impairments. LÄS MER