Sökning: "DNA Isolation"

Visar resultat 21 - 25 av 74 avhandlingar innehållade orden DNA Isolation.

  1. 21. Early diagnosis of cytomegalovirus infection using monoclonal antibodies and DNA amplification

    Författare :Benita Zweygberg Wirgart; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cytomegalovirus; monoclonal antibodies; polymerase chain reaction; CMV early antigen; CMV pp65antigen.;

    Sammanfattning : Human cytomegalovirus (HCMV) is ubiquitous and frequently infects normal individuals with few serious clinical consequences. However, patients with impaired cellular immunity frequently develop life-threatening opportunistic HCMV infections due to either primary infection or reactivation of latent virus. LÄS MER

  3. 22. The efficacy of bacterial viruses against multi-resistant Escherichia coli: from isolation to pharmacology

    Författare :Mohammadali Khan Mirzaei; Anders Nilsson; Rob Lavigne; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phage therapy; Multiresistant E. coli; Pharmacodynamics; Pharmacokinetics; Bacterial viruses; Genomic; proteomic; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The increase of multi-resistant bacteria highlights that the golden era of antibiotics is ending and that alternative treatmentsare urgently needed. Phages have been historically used to treat bacterial infections prior to the discovery of antibiotics and have gained renewed interest in the past decade. LÄS MER

  4. 23. Biomonitoring of epichlorohydrin and some related compounds

    Författare :Helena Hindsø Landin; Bo Jönsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; DNA Adducts; Epichlorohydrin; Glycidol; Hemoglobin adducts.; Physical Biology; fysikalisk biologi;

    Sammanfattning : This thesis considers epichlorohydrin (ECH), an important industrial chemical, that has been shown to be a carcinogen in experimental animals. The aim of this work is to improve the scientific basis for risk estimation of ECH and to suggest a reliable biomonitoring method for exposure. LÄS MER

  5. 24. Genomic studies of expanded trinucleotide repeats : focus on neuropsychiatric disorders

    Författare :Kerstin Lindblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :affective disorder; CTG18.1; DNA; ERDA1; expanded trinucleotide repeats; gene isolation; mutation; Parkinson s disease; repeat expansion detection; repeat instability; spinocerebellar ataxia;

    Sammanfattning : In a number of neurological and neuropsychiatric disorders, a worsening of the disease phenotype from one generation to the next has been linked to expanded trinucleotide repeat sequences that increase in size upon transmission. The clinical phenomenon of an earlier age of onset or a more severe phenotype in later generations of a family has been termed anticipation. LÄS MER

  7. 25. Mammalian cell cycle regulation : characterisation of three genes expressed in proliferating cells

    Författare :Maria Starborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; DNA replication; licensing factor; mitosis; ceheckpoint regulator; centromere regions; cell proliferation marker; nucleolar protein; spermatogenesis;

    Sammanfattning : Proliferating cells undergo different phases in their life cycle. During interphase the cells grow and duplicate their DNA content, followed by a cell division phase, mitosis, which results in two daughter cells. LÄS MER