Sökning: "Neoplastic"

Visar resultat 1 - 5 av 116 avhandlingar innehållade ordet Neoplastic.

  1. 1. p53 and neoplastic progression in Barrett's esophagus

    Författare :Stig Ramel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Barrett s esophagus; neoplastic progression; flow cytometry; p53 gene; p53protein; 17p allelic loss; p53 mutations; S phase fractions; aneuploidy; SV 40 large T antigen; elastase-SV 40 T antigen transgenic mice.;

    Sammanfattning : Barrett's esophagus is a condition in which the normal squamous epithelium is replaced by columnar epithelium as a response to acid reflux. It develops as a complication in 10-20% of patients with gastroesophageal reflux disease. LÄS MER

  3. 2. G1-phase cyclin expression in neoplastic B cells

    Författare :Richard Scuderi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; G1 phase; cyclin D; cyclin E; EBV; Burkitt s; B-ALL; B-CLL; apoptosis;

    Sammanfattning : By virtue of the role of G1-phase cyclin proteins as regulators of differentiation, proliferation, and apoptosis, their improper expression can lead to altered cellular homeostasis and tumor formation. Cyclins provide the regulatory partner for cyclin-cdk complexes whose enzymatic activity drives cell cycle progression. LÄS MER

  4. 3. Telomere analysis of normal and neoplastic hematopoietic cells : studies focusing on fluorescence in situ hybridization and flow cytometry

    Författare :Magnus Hultdin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; telomere; telomerase; fluorescence in situ hybridization; flow cytometry; flow-FISH; replication timing; chronic lymphocytic leukemia; immunoglobulin gene; prognosis; Biomedicin; Microbiology; Mikrobiologi; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : The telomeres are specialized structures at the end of the chromosomes composed of the repeated DNA sequence (TTAGGG)n and specific proteins bound to the DNA. The telomeres protect the chromosomes from degradation and end to end fusions. LÄS MER

  5. 4. Human secretoglobins in normal and neoplastic cells and tissues

    Författare :Anna Sjödin; Håkan Hedman; Roger Henriksson; Mårten Fernö; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; secretoglobins; mammaglobin; lipophilin; breast cancer; pituitary; sweat gland; Onkologi; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : Secretoglobins is a newly described polypeptide family that has gained a lot of interest in human cancer and inflammation research. Although the first secretoglobin polypeptide was discovered more than 30 years ago, their physiological function is still not known. LÄS MER

  7. 5. Endothelin-1-immunoreactive protein and neuroendocrine differentiation and nerve supply in human non-neoplastic and neoplastic adrenal cortex : Immunohistochemical, ultrastructural, and biochemical findings

    Författare :Qing Li; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; adrenal cortex; human; endothelin-related protein; innervation; neuroendocrinedifferentiation; immunohistochemistry; electron microscopy; biochemistry; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : The occurrence and distribution of endothelin (ET)-1-immunoreactive (ir) protein, neuro-endocrine markers and neurohormonal peptides in endocrine cells and nerves in human non-neoplastic and neoplastic adrenal cortex are described.ET-1-ir cell groups were regularly seen in human adrenal cortex, mainly in zona fasciculata, but not in the medulla. LÄS MER