Sökning: "Crossover design"
Visar resultat 31 - 35 av 35 avhandlingar innehållade orden Crossover design.
31. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor
Sammanfattning : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. LÄS MER
32. Measures to prevent microembolization in cardiac surgery and during angiography with special reference to carbon dioxide
Sammanfattning : Background: Cardiovascular interventions including open heart surgery using cardiopulmonary bypass (CPB) and coronary angiography may introduce air and particulate arterial embolism that may lead to tissue lesions of the brain and other organs. Aims: To assess: if CO2-insufflation of an empty CPB circuit decreases number of gaseous emboli in the prime compared with a conventional CPB circuit, which holds air before fluid priming (Study I); the efficacy of a new mini-diffuser device for CO2 de-airing in a minimally invasive open cardiothoracic wound cavity model and in patients undergoing minimally invasive open aortic valve surgery (Study II); if an extra separate venous reservoir abolishes CO2-insufflation induced hypercapnia and retains sweep gas flow of the oxygenator constant during open heart surgery (Study III); if there is a difference in the incidence of cerebral microemboli when using either the femoral or the radial approach during coronary angiography (Study IV). LÄS MER
33. Central pain in multiple sclerosis : clinical characteristics, sensory abnormalities and treatment
Sammanfattning : In the present research programme the occurrence of pain in MS was investigated, with special emphasis on central pain (CP). Questionnaires were sent to all 429 patients with definite MS in the patient register at our neurology department. LÄS MER
34. Physical workload in surgery : from risk assessments to interventions
Sammanfattning : Surgeons often suffer from work-related musculoskeletal disorders (WMSDs), with the neck, shoulders, and low back being the most affected body sites. Among other factors, the high physical workload has been recognized as a major risk factor contributing to the high occurrence of WMSDs. LÄS MER
35. Objective quantification and analysis of eating behaviour associated with obesity development : from lab to real-life
Sammanfattning : Introduction: The last four decades have seen a marked increase in childhood and adult obesity prevalence, attributed to an “obesogenic” environment. Several genetical, environmental and behavioural factors have been identified that increase the risk of obesity, but treatment outcomes are usually modest and the risk of relapse high. LÄS MER
