Sökning: "Cre recombinase"
Visar resultat 11 - 15 av 15 avhandlingar innehållade orden Cre recombinase.
11. Developing brain and systemic inflammation: a "Toll-like" link with consequences
Sammanfattning : The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. LÄS MER
12. Molecular dissection of Bruton’s tyrosine kinase signaling in hematopoietic cells using RNAi
Sammanfattning : RNA mediated gene silencing, RNA interference (RNAi), has recently been identified in mammalians. This thesis describes the utilization and development of RNAi based tools for signal transduction research. The effects of Bruton s tyrosine kinase (Btk) down-regulation with RNAi have been studied with gene expression profiling in hematopoietic cells. LÄS MER
13. Development of nonviral gene delivery and of anti-gene reagents
Sammanfattning : Although significant progress has been made in the basic science and applications of various non-viral gene delivery systems, the majority of non-viral approaches are still much less efficient than viral vectors, especially for in vivo gene delivery, Therefore, non-viral gene delivery must be developed in order to increase the efficiency of in vivo delivery. Moreover, a novel anti-gene reagent was developed for sequence-specific gene silencing. LÄS MER
14. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease
Sammanfattning : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. LÄS MER
15. Studies on adult stem cells
Sammanfattning : While our bodies are aging, in quite a few tissues, new cells are born every day, till the day we die. As you are reading this sentence, there is perhaps a new neuron born in your brain (and some are dying). LÄS MER