Sökning: "Complement dysregulation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Complement dysregulation.

  1. 1. Aspects of Complement Activation in Thrombocytopenic Disorders

    Författare :Alexander Åkesson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thrombocytopenia; Complement activation; Complement dysregulation; Thrombotic microangiopathy; Atypical hemolytic uremic syndrome; Platelet transfusion refractoriness;

    Sammanfattning : The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. LÄS MER

  3. 2. Gene expression in human adipose tissue. Studies of leptin and genes selected by expression profiling

    Författare :Britt Gabrielsson; Göteborgs universitet; []
    Nyckelord :obesity; subcutaneous; omental; DNA microarray; sulfonylurea receptor; fibroblast; growth factors; complement system; fibroblast;

    Sammanfattning : Obesity, and in particular the amount of visceral adipose tissue, is correlated to development of type 2diabetes and cardiovascular disease. The aim of this thesis was to study genes expressed in humanadipose tissue that could be involved in regional adipose tissue homeostasis and/or obesity-associateddisease. LÄS MER

  4. 3. Dysregulation of the immune system in chronic kidney disease and the impact on disease manifestations and co-morbidity

    Författare :Senka Sendic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease and infections. Both conditions share the same underlying cause comprising of changes in innate and adaptive immunity. LÄS MER

  5. 4. Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response

    Författare :Hani Abdulkadir Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of hematopoiesis, including somatic heterozygous mutations, cytogenetic aberrations, or epigenetic aberrations, are found in hematological malignancies. LÄS MER

  7. 5. The pain profile in fibromyalgia : Painomic studies of pain characteristics and proteins in blood

    Författare :Karin Wåhlén; Bijar Ghafouri; Björn Gerdle; Mika Gustafsson; Manuela Schmidt; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Chronic widespread pain (CWP), including fibromyalgia (FM), is a complex pain condition, where little is known about the molecular mechanisms contributing to its pathophysiology. To date, there are no established biomarkers for CWP/FM. LÄS MER