Sökning: "CYP2E1"

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet CYP2E1.

  1. 6. Genetic polymorphism and regulation of cytochrome P450 2E1

    Författare :Yin Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 2E1 (CYP2E1) participates in the metabolism of several xenobiotics. A physiological role of CYP2E1 is its ability to convert acetone into gluconeogenetic precursors. Due to a pronounced oxidase activity CYP2E1 can generate substantial amount of oxygen free radicals and may contribute to oxidative stress. LÄS MER

  3. 7. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease

    Författare :Haydeh Niazi Shahabi; Göteborgs universitet; []
    Nyckelord :cytochrome P450 2E1; dopamine; substantia nigra; polymorphism; alternative splicing;

    Sammanfattning : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. LÄS MER

  4. 8. Molecular basis and structural determinants for the cellular localization of cytochrome P450 2E1

    Författare :Etienne P A Neve; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 2E1 (CYP2E1) is the alcohol inducible member of the P450 family and has a role in gluconeogenesis under fasting conditions. However, CYP2E1 is mainly of toxicological significance and metabolizes xenobiotics to their carcinogenic and toxic metabolites and generates active oxygen species that can cause lipid peroxidation and apoptosis, processes observed in alcoholic liver disease (ALD). LÄS MER

  5. 9. Cytokines, alcohol metabolizing enzymes and stress-inducible ER proteins in alcoholic liver disease

    Författare :Che Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The release of inflammatory cytokines by Kupffer cells is believed to be a key step in the pathogenesis of alcoholic liver disease (ALD). Kupffer cells are activated not only by endotoxins [lipopolysaccharides (LPS)] but also by the lipid peroxidation products generated mainly via ethanol-inducible cytochrome P450 2E1 (CYP2E1) redox cycling. LÄS MER

  7. 10. Uptake, disposition and acute effects of inhaled organic solvents : sex differences and influence of cytochrome P450 2E1 in human volunteers

    Författare :Lena Ernstgård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main aim of the present thesis was to study the influence of sex, cytochrome P450 2E1 and chlorzoxazone on the uptake and metabolism of solvents in humans. Sex differences in acute effects of organic solvents were also assessed. LÄS MER