Sökning: "CYP1A"

Visar resultat 16 - 17 av 17 avhandlingar innehållade ordet CYP1A.

  1. 16. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment

    Författare :Nick Fletcher; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. The aims of this thesis were (1) to clarify the species and strain sensitivity of TCDDinduced retinoid disruption and (2) to identify cellular targets of TCDD-induced retinoid disruption. LÄS MER

  3. 17. Disruption of vitamin A metabolism by dioxin

    Författare :Pi Högberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TCDD; dioxin; vitamin A; retinoic acid; cellular retinol-binding protein; bone;

    Sammanfattning : Vitamin A (retinoids) is a nutrient that plays a central role in development and remains essential for cell growth and differentiation throughout life. Dioxins are polychlorinated organic pollutants known to negatively affect the storage and body clearance of retinoids. LÄS MER