Sökning: "CYP1A"

Visar resultat 6 - 10 av 17 avhandlingar innehållade ordet CYP1A.

  1. 6. Physico-chemical characteristics and quantitative structure-activity relationships of PCBs

    Författare :Patrik Andersson; Stephen Safe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polychlorinated biphenyls; PCBs; physico-chemical properties; statistical design; multivariate; PCA; PLS; biomagnification; BMF; bioassay; CYP1A; SAR; QSAR; REPs; risk assessment; Chemistry; Kemi; Chemistry; Kemi;

    Sammanfattning : The polychlorinated biphenyls (PCBs) comprise a group of 209 congeners varying in the number of chlorine atoms and substitution patterns. These compounds tend to be biomagnified in foodwebs and have been shown to induce an array of effects in exposed organisms. LÄS MER

  3. 7. Evaluation of Biomarker Responses in Fish : with Special Emphasis on Gill EROD Activity

    Författare :Carin Andersson; Jan Örberg; Björn Brunström; Lars Förlin; Uppsala universitet; []
    Nyckelord :Biology; three-spined stickleback; biomarker; EROD; ethynylestradiol; gill; vitellogenin; spiggin; CYP1A inducers; humic substances; sperm quality; biomonitoring; Biologi;

    Sammanfattning : Many chemicals present in the aquatic environment can interfere with physiological functions in fish. Exposure to chemicals can be revealed by the use of biomarkers. Induction of 7-ethoxyresorufin O-deethylase (EROD) activity is a commonly used biomarker for exposure to CYP1A inducers such as dioxins and polyaromatic hyrdrocarbons. LÄS MER

  4. 8. Basal and Pollutant-induced Expression of CYP1A, 1B and 1C isoforms in Fish : Implications for Biomonitoring

    Författare :Kai Gao; Ingvar Brandt; Maria E. Jönsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Aquatic wildlife are exposed to contaminants in their natural habitats, and toxic pollutants may induce toxicity in sensitive target tissues and cells. There is therefore a need to establish biomarkers to determine exposure to certain classes of contaminants and the subsequent biological responses. LÄS MER

  5. 9. Bioactivation and binding of polycyclic aromatic hydrocarbons in blood vessel endothelia

    Författare :Lizette Granberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Polycyclic aromatic hydrocarbon; PAH; endothelial cells; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed by incomplete combustion of organic materials such as fossil fuels and wood. Experimental and epidemiological studies indicate that PAHs may be involved in the development of cardiovascular disease. LÄS MER

  7. 10. Metabolism-dependent activation of food and environmental mutagens in endothelial cells

    Författare :Anita Annas; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : The endothelial cells of blood vessels have been proposed as a target for toxic effects ofxenobiotics in the cardiovascular system. In the present studies, induction of cytochromeP450 1A (CYP1A) enzymes and metabolic activation of food and environmentalmutagens were examined in endothelial cells of rodents, birds, and humans. LÄS MER