Sökning: "Amyotrophic lateral sclerosis"

Visar resultat 21 - 25 av 86 avhandlingar innehållade orden Amyotrophic lateral sclerosis.

  1. 21. Metabolic disorders in the etiology of amyotrophic lateral sclerosis : an epidemiological approach

    Författare :Daniela Mariosa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a loss of motor neurons in the brain and spinal cord, leading to progressive muscle weakness in multiple regions of the body. No effective treatment is available and the disease progresses rapidly to death with an average survival time of 3-5 years after symptom onset. LÄS MER

  3. 22. Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation : nationwide epidemiological studies on etiology, comorbidities, and treatment

    Författare :Elisa Longinetti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease characterized by progressive muscle paralysis, due to loss of upper and lower motor neurons. Signs of neuroinflammation have been reported in ALS, however it is still unknown whether neuroinflammation is a cause or a consequence of the motor neuron dysfunction. LÄS MER

  4. 23. Studies on the phenotype of LXRβ-/- mice : from malabsorption to amyotrophic lateral sclerosis

    Författare :Chiara Gabbi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Liver X Receptors, LXRalpha and LXRbeta (NR1H2) are nuclear receptors belonging to the superfamily of ligand-activated transcription factors with a key role in the control of lipid and glucose metabolism. Studies of the phenotype of LXRalpha-/-mice and LXRbeta-/-mice have shown that these nuclear receptors have specific and distinct roles, although they share very high sequence homology (78%). LÄS MER

  5. 24. Lifestyle risk factors for Parkinson disease and amyotrophic lateral sclerosis : an epidemiological perspective

    Författare :Elin Roos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Following progressive aging of the population, the global prevalence of PD and ALS is expected to increase in the next decades. Primary prevention of the diseases is hampered by limited knowledge of preventable causes. LÄS MER

  7. 25. Cholinergic mechanisms in the spinal cord : topographical localizations of choline acetyltransferase and neuroreceptors and their changes in amyotrophic lateral sclerosis

    Författare :Per-Göran Gillberg; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER