Sökning: "wild-type"

Visar resultat 21 - 25 av 1022 avhandlingar innehållade ordet wild-type.

  1. 21. The SHB adaptor protein in human and murine leukemia

    Författare :Maria Jamalpour; Michael Welsh; Edvard Smith; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The SHB adaptor protein operates downstream of tyrosine kinase receptors. It has been found previously that Shb deficiency in hematopoietic stem cells (HSCs) results in less proliferation and failure to maintain the myeloid compartment over time. LÄS MER

  3. 22. Superoxide dismutase 1 and cataract

    Författare :Eva Olofsson; Anders Behndig; Stefan Marklund; Marjorie Lou; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cataract; diabetes mellitus; nitric oxide; superoxide; superoxide dismutase; SOD1 null mice; Ophtalmiatrics; Oftalmiatrik; oftalmiatrik; Ophtalmology;

    Sammanfattning : Light and oxygen generate harmful reactive oxygen species (ROS) in the lens, causing biochemical changes that gradually disarrange the lens fibres resulting in light scattering and loss of transparency. In the healthy eye, this chronic exposure to oxidative stress may lead to age-related cataract. LÄS MER

  4. 23. Plant Calreticulins - isoforms, localization and function

    Författare :Karin Svensson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; arabidopsis thaliana; calcium; isoform; endoplasmic reticulum; chaperone; tunicamycin;

    Sammanfattning : Calreticulin (CRT) is an endoplasmic reticulum (ER)-located protein involved in quality control of newly synthesized proteins as well as in calcium homeostasis of the cell. Most of what is known about CRT arises from studies of mammalian systems. LÄS MER

  5. 24. Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development

    Författare :Anders Dagälv; Lena Kjellén; Svein Kolset; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sullfate; heparin; proteoglycan; NDST1; NDST2; coreprotein; syndecan; Biochemistry; Biokemi; Cell biology; Cellbiologi; Biokemi; Biochemistry;

    Sammanfattning : Heparan sulfate (HS) is a sulfated glycosaminoglycan expressed by all cells in the body. It is found at the cell surface and in the extracellular matrix where it binds a large amount of various ligands including growth factors and morphogens. LÄS MER

  7. 25. EXT Proteins in Heparan Sulfate Biosynthesis

    Författare :Marta Busse; Marion Kusche-Gullberg; Tarja Kinnunen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) is a long unbranched polysaccharide composed of alternating glucosamine and hexuronic (glucuronic or iduronic) acid residues. Modification by sulfate groups in various positions generates a highly heterogeneous molecule. LÄS MER