Sökning: "Edvard Smith"

Hittade 4 avhandlingar innehållade orden Edvard Smith.

  1. 1. Links between activation and cytoskeletal regulation of B lymphocytes

    Författare :Gediminas Greicius; Edvard Smith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Zoological Developmental Biology; zoologisk utvecklingsbiologi;

    Sammanfattning : Interplay between adhesion molecules and the cytoskeleton is involved in many aspects of B lymphocyte behaviour during an immune response. Events such as cell polarisation and locomotion, collaboration with T lymphocytes and segregation in secondary lymphoid tissues all include mechanisms that recognise microenvironment and accordingly adjust morphological features of the cell. LÄS MER

  3. 2. The SHB adaptor protein in human and murine leukemia

    Författare :Maria Jamalpour; Michael Welsh; Edvard Smith; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The SHB adaptor protein operates downstream of tyrosine kinase receptors. It has been found previously that Shb deficiency in hematopoietic stem cells (HSCs) results in less proliferation and failure to maintain the myeloid compartment over time. LÄS MER

  4. 3. Rational modifications of cell-penetrating peptides for drug delivery : Applications in tumor targeting and oligonucleotide delivery

    Författare :Maarja Mäe; Ülo Langel; Edvard Smith; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; oligonucleotide; drug delivery; tumor targeting; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : High molecular weight biomolecules are becoming important in the development of new therapeutics. However, their size and nature creates a major limitation for their application – poor penetration through biological membranes. LÄS MER

  5. 4. Regulation of PDGFRβ signaling 

    Författare :Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. LÄS MER