Sökning: "stem progenitor cells"

Visar resultat 21 - 25 av 264 avhandlingar innehållade orden stem progenitor cells.

1. 21. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

   Författare :Nicolaj Christophersen; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; neurotrophic factors; Parkinson s disease; microarray; dopaminergic; Embryonic stem cells; neural stem cells;

   Sammanfattning : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. LÄS MER

3. 22. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

   Författare :Niels-Bjarne Woods; Andreas Ooka; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi; Lentivirus : genetics; Human; Genetic Vectors; Hematopoietic Stem Cells : metabolism; Animal; Gene Therapy; Leukemia : therapy; Leukemia : metabolism;

   Sammanfattning : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. LÄS MER

4. 23. Stem and progenitor cell involvement in acute lymphoblastic leukemia

   Författare :Anders Castor; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Haematology; Cytology; oncology; cancerology; Cytologi; onkologi; Medicin människa och djur ; Medicine human and vertebrates ; ETV6-RUNX1; BCR-ABL1; stem cells; Acute lymphoblastic leukemia; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. LÄS MER

5. 24. Studies on adult stem cells

   Författare :Konstantinos Meletis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : While our bodies are aging, in quite a few tissues, new cells are born every day, till the day we die. As you are reading this sentence, there is perhaps a new neuron born in your brain (and some are dying). LÄS MER

7. 25. Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche

   Författare :Kristina Vukusic; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart; cardiac stem cells; Stem cell niche; Atrioventricular junction; Side population; 3D culture;

   Sammanfattning : Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac cells was shown in humans, around 1%/year. As a source for this regeneration endogenous stem cells have been suggested. LÄS MER