Sökning: "dopaminergic"
Visar resultat 1 - 5 av 251 avhandlingar innehållade ordet dopaminergic.
1. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems
Sammanfattning : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. LÄS MER
2. Dopaminergic 2-aminotetralins : synthesis, conformational analysis, and structure-activity relationships
Sammanfattning : .... LÄS MER
3. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells
Sammanfattning : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. LÄS MER
4. Functional and Transcriptional Studies of Human Dopaminergic Neurons
Sammanfattning : Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). LÄS MER
5. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells
Sammanfattning : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. LÄS MER