Sökning: "ETV6-RUNX1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet ETV6-RUNX1.

  1. 1. Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia

    Författare :Henrik Lilljebjörn; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SNP array; array CGH; ETV6 RUNX1-positive ALL; childhood ALL; exome sequencing;

    Sammanfattning : The t(12;21) translocation generates the ETV6/RUNX1 fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. LÄS MER

  3. 2. Stem and progenitor cell involvement in acute lymphoblastic leukemia

    Författare :Anders Castor; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Haematology; Cytology; oncology; cancerology; Cytologi; onkologi; Medicin människa och djur ; Medicine human and vertebrates ; ETV6-RUNX1; BCR-ABL1; stem cells; Acute lymphoblastic leukemia; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. LÄS MER

  4. 3. Pediatric Leukemia: Mechanisms of Initiation and Suppression

    Författare :Mohamed Eldeeb; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ETV6-RUNX1; Leukemia Initiation; MLL-rearrangements; Hematopoietic stem cells; LIN28B;

    Sammanfattning : .... LÄS MER

  5. 4. Prognostic molecular markers of childhood leukemia

    Författare :Fredrika Gauffin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute lymphoblastic leukemia; dic 9; 20 ; dried blood spots; Guthrie card; RNA; PTEN; SHP1; VEGF; VEGFR-1; VEGFR-2; immuhistochemistry; tissue micro array;

    Sammanfattning : During the last decades there has been a dramatic increase in survival rates for childhood leukemia, resulting today in an overall survival close to 90 % for children with acute lymphoblastic leukemia (ALL). This accomplishment is largely due to treatment protocols based on careful risk group assessment guiding the type and intensity of the anti-leukemic treatment. LÄS MER

  7. 5. On the origin of B cells. Elucidating the Role of Tyrosine Kinase Receptors in B Cell Development

    Författare :Alya Zriwil; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; B cell development; cytokine; tyrosine kinase receptors;

    Sammanfattning : B cells are essential cells that are part of the adaptive immune system with the capacity to produce antibodies against exogenous antigens. These cells are produced through a process called hematopoiesis, tightly regulated by extrinsic and intrinsic factors. LÄS MER