Sökning: "ribavirin"

Visar resultat 6 - 10 av 24 avhandlingar innehållade ordet ribavirin.

  1. 6. Innate and adaptive cellular immunity in chronic HCV and HIV-1 infection

    Författare :Veronica D Gonzalez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; HIV-1; co-infection; adaptive immunity; innate immunity; NK cell; NKT cell; CD4 T cell; CD8 T cell; IFNalpha; ribavirin; immune activation;

    Sammanfattning : Viral infections are initially countered by an innate immune response as a first line of defence followed by an adaptive immune response. However, certain viruses successfully evade cellular immune responses and establish chronic infection. LÄS MER

  3. 7. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection

    Författare :Åsa Alsiö; Göteborgs universitet; []
    Nyckelord :infectious diseases; virology; hepatitis c; treatment;

    Sammanfattning : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. LÄS MER

  4. 8. Impact of Host Genetic Variants on Natural History and Treatment of Hepatitis C Virus Infection

    Författare :Karolina Rembeck; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis C; prognostic factors;

    Sammanfattning : Chronic hepatitis C Virus (HCV) infection causes liver disease and may progress to severe fibrosis, cirrhosis, and hepatocellular carcinoma. This thesis aimed to evaluate the impact of host genetics, i.e. LÄS MER

  5. 9. HIV-1/HCV co-infection : immunity and viral dynamics

    Författare :Karolin Falconer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) are the agents behind two viral epidemics causing huge morbidity and mortality worldwide. HCV infection is a leading cause of end-stage liver disease. LÄS MER

  7. 10. Immune modulation in chronic HBV and HCV infection

    Författare :Catharina Hultgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HBV; HBeAg; HCV; NS3; chronic infection; humoral cellular immune response; Th1 Th2 cells; proliferative response;

    Sammanfattning : Chronic viral hepatitis is a major health problem worldwide. The two major viral causes for chronic hepatitis are the hepatitis B (HBV) and C viruses (HCV). HBV is a DNA virus with a rather limited genetic variability whereas HCV is an RNA virus with a high genetic variability. LÄS MER