Sökning: "protein carbonyls"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden protein carbonyls.

  1. 6. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

    Författare :Gabriella Brolén; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

    Sammanfattning : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. LÄS MER

  3. 7. Age pigments and the biochemical basis of their formation

    Författare :Dazhong Yin; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The autofluorescent, yellow-brown pigments that accumulate over time inbiological organisms are called age pigments. Lipofuscin, known as a hallmark of aging, refers to intracellular age pigments that accumulate mainly in the lysosomes of postrnitotic cells. LÄS MER

  4. 8. Insights into Marine Fish Physiology in a Changing World

    Författare :Karine Bresolin de Souza; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ocean acidification; carbon dioxide; temperature; global warming; Hippoglossus hippoglossus; Gasterosteus aculeatus; immune system; energy metabolism enzymes; oxidative stress; proteomics; behaviour;

    Sammanfattning : Ocean acidification and global warming are largely caused by increased levels of atmospheric CO2, and marine fish are exposed to both these stressors simultaneously. Although the effects of temperature on fish have been investigated over the last century, the effects of moderate CO2 exposure and the combination of both stressors are not well-understood, especially long-term effects. LÄS MER

  5. 9. Experimental Helicobacter pylori infection in an animal model

    Författare :Yi-Qian Sun; Torkel Wadström; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Background: Helicobacter pylori is a microaerophilic Gram-negative bacterium colonizing the human stomach. The prevalence of this infection is between 20-90% depending on geographic location. Comprehensive studies have shown significant relationships between H. pylori infection and chronic gastritis, peptic ulcer and gastric carcinoma. LÄS MER

  7. 10. Oxidative stress and mitochondrial function : role of ubiquinol as antioxidant

    Författare :Patrik Andrée; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over the last three decades it has been established that biquinone (coenzyme Q), in addition to its function as an electron and proton carrier in the respiratory chain, acts in its reduced form (ubiquinol) as an antioxidant. The main theme of this thesis is a study of the antioxidant function of ubiquinol in preparations of beef heart submitochondrial particles, which consist of inverted vesicular fragments of the inner mitochondrial membrane. LÄS MER