Sökning: "membrane orientation"

Visar resultat 6 - 10 av 55 avhandlingar innehållade orden membrane orientation.

1. 6. Retinoids and Ruthenium Complexes: Spectroscopic Probes for Lipid Membranes

   Författare :Frida Svensson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; retinoic acid; lipid vesicle; liposomes; dipyridophenazine; orientation; linear dichroism; membrane interaction; ruthenium; lipid chain ordering;

   Sammanfattning : .... LÄS MER

3. 7. Engineering membrane proteins for production and topology

   Författare :Stephen Toddo; Daniel Daley; Roslyn Bill; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane protein; Over-expression; Protein production; Codon optimization; Escherichia coli; AraH; NarK; mRNA secondary structure; coding sequence; ribosome binding site; RBS; topology; split-GFP; Biochemistry; biokemi;

   Sammanfattning : The genomes of diverse organisms are predicted to contain 20 – 30% membrane protein encoding genes and more than half of all therapeutics target membrane proteins. However, only 2% of crystal structures deposited in the protein data bank represent integral membrane proteins. LÄS MER

4. 8. Dual-topology membrane proteins in Escherichia coli

   Författare :Susanna Seppälä; Gunnar von Heijne; Dirk Jan Slotboom; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein topology; dual-topology; evolution; Escherichia coli; Biochemistry; biokemi;

   Sammanfattning : Cellular life, as we know it, is absolutely dependent on biological membranes; remarkable superstructures made of lipids and proteins. For example, all living cells are surrounded by at least one membrane that protects the cell and holds it together. LÄS MER

5. 9. Optical Dyes for Visualization of Structure and Function of Biomolecules and Biological Membranes

   Författare :Maria Matson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Orientation; RNA; Lipid Membranes; Voltage-Sensitive Dyes; Binding Preferences; Cellular Localization; DNA; Spectroscopy; Spectral Properties; Lipophilic Ruthenium Complex;

   Sammanfattning : To visualize the structure and function of biomolecules and biological membranes in the cell, optical dyes are important tools where in particular fluorescent probes provide a sensitive and selective detection. When cellular compartments are investigated it is crucial that the probe selectively binds to the area of interest and not exhibits unspecific binding affinity. LÄS MER

7. 10. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding

   Författare :Tuuli Minttu Virkki de Marothy; Arne Elofsson; William Dowhan; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein folding; hydrophobicity; translocon; transmembrane helix; marginally hydrophobic transmembrane helices; orientational preference; positive inside rule; aquaporin 1; Biochemistry; biokemi;

   Sammanfattning : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. LÄS MER