Sökning: "histone deacetylation"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden histone deacetylation.
1. Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain
Sammanfattning : The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. LÄS MER
2. Transcriptional regulation of the Epstein-Barr virus latent membrane protein 1 gene in B cells
Sammanfattning : Epstein-Barr Virus (EBV) is a ubiquitous human B-lymphotrobic herpesvirus that latently infects over 90 percent of the world´s population. EBV infection is usually benign in healthy people. LÄS MER
3. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells
Sammanfattning : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. LÄS MER
4. Characterisation of CtBP : A Co-Repressor of Transcription that Interacts with the Adenovirus E1A Protein
Sammanfattning : In this study, adenovirus E1A has been used to target and analyse the transcriptional function of the cellular C-terminal Binding Protein (CtBP).Transcription is a complex biochemical process that represents a major regulatory step in gene expression. LÄS MER
5. Chromatin regulators and transcriptional control of Drosophila development
Sammanfattning : The development of a multicellular organism is programmed by complex patterns of gene expression. In eukaryotic cells, genes are packaged by histone proteins into chromatin. Chromatin regulators often function as transcription co-factors. LÄS MER