Sökning: "focal adhesions"
Visar resultat 1 - 5 av 17 avhandlingar innehållade orden focal adhesions.
1. Mechanisms of HAMLET-induced cancer cell death
Sammanfattning : HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. LÄS MER
2. Effects of Th-1 and Th-2 Cytokines and Reactive Oxygen Species on Normal Human Bronchial Epithelial Cells
Sammanfattning : Epithelial damage and shedding of the epithelium are common observations in many airway diseases such as asthma, Sjögren’s syndrome, chronic obstructive pulmonary disease and cystic fibrosis. The ability of the cells to attach to each other and/or to the matrix seems to be altered. LÄS MER
3. Functional studies of integrin subunit 1 and its cytoplasmic domain
Sammanfattning : Integrin subunit β1 can form functional heterodimeric receptors together with at least 11different a subunits. These integrins are the main cellular receptors for extracellular matrixproteins such as collagens, fibronectin, laminins, and others, and they are necessary fornormal embryonal development. LÄS MER
4. Molecular Mechanisms of Action of Histidine-rich Glycoprotein in Angiogenesis Inhibition
Sammanfattning : Angiogenesis, de novo synthesis of blood vessels from the pre-existing vasculature, is required both during embryonic development and in pathophysiological conditions. In particular, tumor growth needs new capillary vessels in order to both deliver oxygen and nutrients and to remove toxin and metabolites. LÄS MER
5. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4
Sammanfattning : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. LÄS MER