Sökning: "alveolar process"

Visar resultat 21 - 25 av 30 avhandlingar innehållade orden alveolar process.

1. 21. Ventilation/Perfusion Matching and its Effect on Volatile Pharmacokinetics

   Författare :Moritz Andreas Kretzschmar; Anders Larsson; Jan Jakobsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anesthesia; Animal models in research; Mass spectrometry; Gas chromatography; MIGET; Ventilation-perfusion; Desflurane; Isoflurane; Bronchoconstriction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Sammanfattning : The mismatching of alveolar ventilation and perfusion (VA/Q) is the major determinant of impaired gas exchange. The gold standard for analyzing VA/Q distribution is the multiple inert gas elimination technique (MIGET), conventionally based on gas chromatography (GC), and, although simple in principle, a technically demanding procedure limiting its use. LÄS MER

3. 22. Physiologically based pharmacokinetic modeling in risk assessment - Development of Bayesian population methods

   Författare :Fredrik Jonsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; methyl chloride; dichloromethane; toluene; styrene; uncertainty; intra- individual variability; risk assessment; physiologically based modeling; Markov chain Monte Carlo; PBPK; Bayesian; population modeling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

   Sammanfattning : In risk assessment of risk chemicals, variability in susceptibility in the population is an important aspect. The health hazard of a pollutant is related to the internal exposure to the chemical, i.e. the target dose, rather than the external exposure. LÄS MER

4. 23. Regional Lung Kinetics of Ventilator-Induced Lung Injury and Protective-Ventilation Strategies Studied by Dynamic Positron Emission Tomography

   Författare :João Batista Borges; Anders Larsson; Giacomo Bellani; Uppsala universitet; []
   Nyckelord :[18F]fluoro-2-deoxy-D-glucose; positron emission tomography; acute pulmonary inflammation; acute respiratory distress syndrome; mechanical ventilation; ventilator-induced lung injury;

   Sammanfattning : Mechanical ventilation in itself can harm the lung and cause ventilator-induced lung injury (VILI), which can induce or aggravate acute respiratory distress syndrome (ARDS). Much debate remains over pivotal concepts regarding the pathophysiology of VILI, especially about the precise contribution, kinetics, and primary role of potential VILI mechanisms. LÄS MER

5. 24. Regulation of Hedgehog signalling during development and carcinogenesis

   Författare :Marie Fiaschi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hedgehog (Hh) signalling is one of the most important signalling networks in the body and, when miss-regulated, has been implicated in many human tumours, particularly that of skin (Basal Cell Carcinoma, BCC) and brain (medulloblastoma). BCC most commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). LÄS MER

7. 25. Mechanisms of neutrophil recruitment in septic lung injury

   Författare :Karzan Palani; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; infection; neutrophil; lung; chemokines; apoptosis; CD44; F-actin; peptides;

   Sammanfattning : Sepsis is one of leading cause of death despite aggressive surgical intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. LÄS MER