Sökning: "Simon Tuck"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Simon Tuck.

  1. 1. The control of growth and metabolism in Caenorhabditis elegans

    Författare :Josefin Friberg; Simon Tuck; Cathy Savage-Dunn; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TGFβ; insulin; collagen; p70 S6K; metabolism; growth; dauer; Caenorhabditis elegans; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The control of growth is a poorly understood aspect of animal development. This thesis focuses on body size regulation in Caenorhabditis elegans, and in particular, how worms grow to a certain size. In C. elegans, a key regulator of size is the TGFβ homologue DBL-1. LÄS MER

  3. 2. The Molecular Mechanism of Aggression and Feeding Behaviour in Drosophila melanogaster

    Författare :Philip Goergen; Helgi Schiöth; Michael Williams; Simon Tuck; Uppsala universitet; []
    Nyckelord :Drosophila; aggression; obesity; homeostasis;

    Sammanfattning : Obesity is a complex disorder which has become a growing health concern. Twin studies have demonstrated a strong genetic component to the development of obesity and genome wide association studies have identified several genetic loci associated with it. However, most of these loci are still poorly understood in a functional context. LÄS MER

  4. 3. A molecular exploration of sensory responses in c. elegans

    Författare :Longjun Pu; Changchun Chen; Simon Tuck; Sara I Wilson; Zhiyong Shao; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; C. elegans; sensation; CRISPR Cas9; G protein-coupled receptors; neuropeptides; acute hypoxia; pathogen; chemosensation; hydrogen sulfide; HIF-1; iron;

    Sammanfattning : Sensation provides a pivotal ability, allowing animals to survive in complex environments. The cues sensed by animals are represented by external stimuli and internal signals. However, the mechanisms mediating sensations in molecular and cellular level are still not well-studied. In this thesis, by using free-living nematodes C. LÄS MER

  5. 4. Studies on lipid transport and extracellular vesicle production in Caenorhabditis elegans ciliated neurons

    Författare :Shapour Rahmani; Simon Tuck; Jonathan D. Gilthorpe; Anders Olsen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C. elegans; cilia; extracellular vesicles; tat; phospholipid translocase; P4-family ATPase;

    Sammanfattning : The cilium is a protrusion of cell membrane. Both the protein and lipid contents of cilia are different from those of other parts of the cell membrane. While the transport of proteins into and out of cilia has been intensively studied, much less is known about how the lipid content of ciliary membranes is regulated. LÄS MER

  7. 5. Regulation of energy balance in Caenorhabditis elegans 

    Författare :Ming Sheng; Simon Tuck; Lars Nilsson; Carina Holmberg-Still; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C.elegans; fat metabolism; S6 Kinase; FT-IR; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Sammanfattning : Obesity is a medical condition in which excess body fat has been accumulated. It is most commonly caused by imbalance between energy intake and energy expenditure (lack of physical activity and lower metabolic rate, etc.). LÄS MER