Sökning: "STN"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet STN.

  1. 1. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Författare :Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER

  3. 2. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation

    Författare :Adriane Guillaumin; Åsa Wallén-Mackenzie; Konstantinos Meletis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Subthalamic nucleus; optogenetics; basal ganglia; locomotion; Parkinson s disease; aversion; Neuroscience; Neurovetenskap;

    Sammanfattning : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. LÄS MER

  4. 3. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease

    Författare :Marko Filipović; Jeanette Hellgren Kotaleski; Arvind Kumar; Gilad Silberberg; Ad Aertsen; Andrew Sharott; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; basal ganglia; striatum; medium spiny neurons; subthalamic nucleus; globus pallidus; Parkinson s disease; in vivo; oscillations; spectral analysis; response variability; networks; simulations; modelling; Numerical Analysis; Numerisk analys; Computer Science; Datalogi; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Sammanfattning : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. LÄS MER

  5. 4. Balance performance in people with Parkinson’s disease. Effects of subthalamic Deep Brain Stimulation

    Författare :Maria H Nilsson; Aktivt och hälsosamt åldrande; []
    Nyckelord :Parkinson s disease; Deep Brain Stimulation; subthalamic nucleus; balance; falls.; fear of falling;

    Sammanfattning : The overall aims of this work were to investigate if Deep Brain Stimulation in the subthalamic nuclei (STN) affected balance, fear of falling and falls in people with Parkinson's disease. The effect of STN stimulation alone was investigated in Papers I, II and III. LÄS MER

  7. 5. Utility of novel drug targets for treatment of metastatic cancer

    Författare :Tianyan Wang; Jenny Persson; Thomas Grundström; Maréne Landström; Margareta Wilhelm; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic cancer; castration-resistant prostate cancer; pancreatic ductal adenocarcinoma; target therapy; PIP5K1α; KRAS; molecularly imprinted polymers; Oncology; onkologi; molekylärbiologi; Molecular Biology; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. LÄS MER